|
Consisting of about 110 amino acids, the domain in winged-helix transcription factors has four helices and a two-strand beta-sheet.
These proteins are classified into 17 families called FoxA-FoxQ.
Mutations in FoxP proteins are implicated in human autoimmune diseases.
See also
External links
|
Transcription factors and intracellular receptors |
|
|
(1) Basic domains |
|
|
|
Activating transcription factor ( AATF, 1, 2, 3, 4, 5, 6, 7) AP-1 ( c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) BACH ( 1, 2) BATF BLZF1 C/EBP ( a, ί, ?, d, e, ?) CREB ( 1, 3, L1) CREM DBP DDIT3 GABPA HLF MAF ( B, F, G, K) NFE ( 2, L1, L2) NRL NRF1 XBP1
|
|
(1.2) Basic helix-loop-helix ( bHLH)
|
ATOH1 AhR AHRR ARNT ASCL1 BHLHB2 BMAL ( ARNTL, ARNTL2) CLOCK EPAS1 HAND ( 1, 2) HES ( 5, 6) HEY ( 1, 2, L) HES1 HIF ( 1A, 3A) ID ( 1, 2, 3, 4) LYL1 MXD4 MYCL1 MYCN Myogenic regulatory factors ( MyoD, Myogenin, MYF5, MYF6) Neurogenins NeuroD ( 1, 2) NPAS ( 1, 2, 3) OLIG ( 1, 2) Scleraxis TAL1 Twist USF1
|
|
|
|
|
|
|
(1.4) NF-1
|
|
|
|
(1.5) RF-X
|
|
|
|
(1.6) Basic helix-span-helix (bHSH)
|
|
|
|
|
|
(2) Zinc finger DNA-binding domains |
|
|
|
subfamily 1 ( Thyroid hormone ( a, ί), CAR, FXR, LXR ( a, ί), PPAR ( a, ί/d, ?), PXR, RAR ( a, ί, ?), ROR ( a, ί, ?), Rev-ErbA ( a, ί), VDR)
subfamily 2 ( COUP-TF ( I, II), Ear-2, HNF4 ( a, ?), PNR, RXR ( a, ί, ?), Testicular receptor ( 2, 4), TLX)
subfamily 3 ( Steroid hormone ( Androgen, Estrogen ( a, ί), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related ( a, ί, ?))
subfamily 4 NUR ( NGFIB, NOR1, NURR1) subfamily 5 ( LRH-1, SF1) subfamily 6 ( GCNF) subfamily 0 ( DAX1, SHP)
|
|
|
(2.2) Other Cys4
|
|
|
|
(2.3) Cys2His2
|
General transcription factors ( TFIIA, TFIIB, TFIID, TFIIE, TFIIF ( 1, 2), TFIIH ( 1, 2, 4, 2I, 3A, 3C1, 3C2))
ATBF1 BCL ( 6, 11A, 11B) CTCF E4F1 EGR ( 2, 3) ERV3 GFI1 GLI-Krόppel family ( 1, 2, 3, S2, YY1) HIC ( 1, 2) HIVEP ( 1, 2, 3) IKZF ( 1, 2, 3) ILF ( 2, 3) KLF ( 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17 ) MTF1 MYT1 OSR1 SP ( 1, 2, 4, 7) Zbtb7 ( 7A, 7B) ZBTB ( 16, 17, 20, 32, 33, 40) zinc finger ( 3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 649, 655)
|
|
|
(2.4) Cys6
|
|
|
|
(2.5) Alternating composition
|
|
|
|
|
|
(3) Helix-turn-helix domains |
|
|
|
ARX CDX ( 1, 2) CRX CUTL1 DLX ( 3, 4, 5) EMX2 EN ( 1, 2) FHL ( 1, 2, 3) HESX1 HHEX HLX Homeobox ( A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) HOPX MEIS ( 1, 2) MEOX2 MNX1 MSX ( 1, 2) NANOG NKX ( 2-1, 2-2, 2-3, 2-5, 3-1, 3-2) PBX ( 1, 2, 3) PHF ( 1, 3, 6, 8, 10, 16, 17, 20, 21A) PITX ( 1, 2, 3) POU domain ( PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) OTX ( 1, 2) PDX1
|
|
|
(3.2) Paired box
|
|
|
|
|
E2F ( 1, 2, 3, 4, 5) FOX proteins ( C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, O3A, O4, P1, P2, P3)
|
|
|
|
|
|
|
(3.5) Tryptophan clusters
|
ELF ( 4, 5) EGF ELK ( 1, 3, 4) ERF ERG ETS ( 1, 2, SPIB) ETV ( 1, 4, 5, 6) FLI1 Interferon regulatory factors ( 1, 2, 3, 4, 5, 6, 7, 8) MYB MYBL2
|
|
|
(3.6) TEA domain
|
transcriptional enhancer factor 1, 2
|
|
|
|
|
(4) ί-Scaffold factors with minor groove contacts |
|
|
(4.1) Rel homology region
|
|
|
|
|
|
|
|
(4.3) p53
|
|
|
|
|
|
|
|
|
|
|
|
|
HMGB ( 1, 2, 3) HNF ( 1A, 1B) LEF1 SOX ( 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) SRY SSRP1 TOX ( 1, 2, 3, 4)
|
|
|
(4.10) Cold-shock domain
|
|
|
|
(4.11) Runt
|
|
|
|
|
|
(0) Other transcription factors |
|
|
(0.2) HMGI(Y)
|
|
|
|
|
|
|
|
|
|
|
|
(0.6) Miscellaneous
|
ARID ( 1A, 1B, 2, 3A, 3B, 4A) CAP IFI ( 16, 35) MLL ( 2, 3, T1) MNDA NFI ( A, B, C, X) NFY ( A, B, C) Rho/ Sigma R-SMAD
|
|
|
|
| |
