|
Top7 is an artificial 93-amino acid protein, classified as a de novo protein since it was designed by Brian Kuhlman in David Baker's laboratory at the University of Washington and the Fred Hutchinson Cancer Research Center to have a unique fold not found in nature.[1] The protein was designed ab initio on a computer with the help of protein structure prediction algorithms. X-ray crystallography on the protein after it was made, revealed that the structure was indeed very similar (1.2 Å RMSD) to the computer predicted structure. The structure consists of two alpha helices and two beta sheets.
References
- ^ Kuhlman B, Dantas G, Ireton GC, Varani G, Stoddard BL, Baker D (2003-11-21). "Design of a novel globular protein fold with atomic-level accuracy". Science 302 (5649): 1364-1368. PMID 14631033.
| |
