In enzymology, an omega-amidase (EC 3.5.1.3) is an enzyme that catalyzes the chemical reaction

a monoamide of a dicarboxylic acid + H₂O a dicarboxylate + NH₃

Thus, the two substrates of this enzyme are monoamide of a dicarboxylic acid and H₂O, whereas its two products are dicarboxylate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is omega-amidodicarboxylate amidohydrolase. This enzyme is also called alpha-keto acid-omega-amidase. This enzyme participates in glutamate metabolism and alanine and aspartate metabolism.

References

• IUBMB entry for 3.5.1.3
• BRENDA references for 3.5.1.3 (Recommended.)
• PubMed references for 3.5.1.3
• PubMed Central references for 3.5.1.3
• Google Scholar references for 3.5.1.3
• MEISTER A, LEVINTOW L, GREENFIELD RE, ABENDSCHEIN PA (1955). "Hydrolysis and transfer reactions catalyzed by omega-amidase preparations". J. Biol. Chem. 215: 441–60. PMID 14392177. 
• Meister A, Radhakrishnan AN and Buckley SD (1957). "Enzymatic synthesis of L-pipecolic acid and L-proline". J. Biol. Chem. 229: 789–800. 

External links

The CAS registry number for this enzyme class is 9025-19-8.

• IUBMB entry for 3.5.1.3

• KEGG entry for 3.5.1.3

• BRENDA entry for 3.5.1.3

• NiceZyme view of 3.5.1.3

• EC2PDB: PDB structures for 3.5.1.3

• PRIAM entry for 3.5.1.3

• PUMA2 entry for 3.5.1.3

• IntEnz: Integrated Enzyme entry for 3.5.1.3

• MetaCyc entry for 3.5.1.3

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0050152: omega-amidase

• AMIGO entry for GO code 0050152: omega-amidase

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