Medicinal cannabis leaf

Medical cannabis refers to the use of the Cannabis sativa plant as a physician-recommended herbal therapy. So far, the medical use of cannabis is legal only in a limited number of territories, including Canada, Belgium, Australia, the Netherlands, the United Kingdom, Spain, and some U.S. states. This usage generally requires a prescription, and distribution is usually done within a framework defined by local laws.

There are many studies regarding the use of cannabis in a medicinal context.^[1][2][3][4]

History

Ancient China

The use of cannabis, at least as fiber, has been shown to go back at least 10,000 years in Taiwan. "Dà má" (Pinyin pronunciation) is the Chinese expression for medicinal cannabis, the first character meaning "big" and the the second character meaning "hemp," a pictograph of 2 cannabis plants inside of a house or sheltered area.

Cannabis sativa from Vienna Dioscurides, 512 A.D.

Cannabis, called dà má (??) in Chinese, is known to have been used in Taiwan for fiber starting about 10,000 years ago.^[7] Cannabis has been used for medicinal purposes for approximately 4,000 years.^[8] Cannabis is also mentioned in The Divine Farmer's Herb-Root Classic, an ancient Chinese pharmacopoeia attributed to Emperor Shennong.^{[citation needed]} Cannabis was prescribed to treat vomiting, infectious and parasitic hemorrhaging.

Ancient Egypt

The Ebers Papyrus (ca. 1,550 B.C.) from Ancient Egypt describes medical marihuana.^[9] The ancient Egyptians even used hemp (cannabis) in suppositories for relieving the pain of hemorrhoids.^[10] The egyptologist Lise Manniche notes the reference to "plant medical marijuana" in several Egyptian texts, one of which dates back to the eighteenth century B.C.^[11]

Ancient India

Surviving texts from ancient India confirm that cannabis' psychoactive properties were recognized, and doctors used it for a variety of illnesses and ailments. These included insomnia, headaches, a whole host of gastrointestinal disorders, and pain: cannabis was frequently used to relieve the pain of childbirth.

Medieval Islamic world

In the medieval Islamic world, Arabic physicians discovered the diuretic, antiemetic, antiepileptic, anti-inflammatory, pain killing and antipyretic properties of cannabis sativa, and used it extensively as medication from the 8th to 18th centuries.^[12]

Modern history

An Irish doctor, William O'Shaughnessy, was held mainly responsible for showing his Western colleagues about the healing properties of marijuana. He was a herb professor at the Medical College of Calcutta, and in conducted a marijuana experiment in the 1830s. O'Shaughnessy created preparations and tested animal effects. He continued on to administer this marijuana to patients in order to help treat muscle spasms or pain.^[13]

An advertisement for cannabis americana distributed by a pharmacist in New York in 1917.

Cannabis as a medicine became common throughout much of the world by the 19th century. It was used as the primary pain reliever until the invention of aspirin.^[8] Modern medical and scientific inquiry began with doctors like O'Shaughnessy and Moreau de Tours, who used it to treat melancholia and migraines, and as a sleeping aid, analgesic and anticonvulsant.

By the time the United States banned cannabis in a federal law, the 1937 Marijuana Tax Act, the plant was no longer extremely popular.^{[citation needed]} Skepticism about marijuana arose in response to the bill.^{[citation needed]}

Later in the century, researchers investigating methods of detecting cannabis intoxication discovered that smoking the drug reduced intraocular pressure.^[14]

In 1972 Tod H. Mikuriya, M.D. reignited the debate concerning marijuana as medicine when he published "Marijuana Medical Papers . "High intraocular pressure causes blindness in glaucoma patients, so many believed that using the drug could prevent blindness in patients. Many Vietnam War veterans also believed that the drug prevented muscle spasms caused by battle-induced spinal injuries. Later medical use has focused primarily on its role in preventing the wasting syndromes and chronic loss of appetite associated with chemotherapy and AIDS, along with a variety of rare muscular and skeletal disorders. Less commonly, cannabis has been used in the treatment of alcoholism and addiction to other drugs such as heroin and the prevention of migraines. In recent years, studies have shown or researchers have speculated that the main chemical in the drug, THC, might help prevent atherosclerosis.

Medical cannabis card in Marin County, California, U.S.A.

Later, in the 1970s, a synthetic version of THC, the primary active ingredient in cannabis, was synthesized to make the drug Marinol. Users reported several problems with Marinol, however, that led many to abandon the pill and resume smoking the plant. Patients complained that the violent nausea associated with chemotherapy made swallowing pills difficult. The effects of smoked cannabis are felt almost immediately, and is therefore easily dosed.^[15] Marinol (Jojel), like ingested cannabis, is very psychoactive, and is harder to titrate than smoked cannabis.^[16] Marinol has also consistently been more expensive than herbal cannabis.^[17] Some studies have indicated that other chemicals in the plant may have a synergistic effect with THC.^[18]

In addition, during the 1970s and 1980s, six U.S. states' health departments performed studies on the use of medical marijuana. These are widely considered some of the most useful and pioneering studies on the subject.^{[citation needed]} Voters in the following eight states showed their support for marijuana prescriptions given by physicians between 1996 and 1999: "Alaska, Arizona, California, Colorado, Maine, Nevada, Oregon, and Washington", going against policies of the federal government.^[19]

In May 2001, "The Chronic Cannabis Use in the Compassionate Investigational New Drug Program: An Examination of Benefits and Adverse Effects of Legal Clinical Cannabis" (Russo, Mathre, Byrne et al) was completed. This three-day examination of major body functions of four of the five living US federal cannabis patients found "mild pulmonary changes" in two patients.^[20]

On October 7, 2003, a patent (#6,630,507) entitled: "Cannabinoids as Antioxidants and Neuroprotectants" was awarded to the United States Department of Health and Human Services, based on research done at the National Institute of Mental Health (NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS). This patent claims that cannabinoids are "useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia." ^[21]

Indications

Cannabis is most importantly indicated as an antiemetic for the treatment of nausea and anorexia associated with treatments for cancer, AIDS, and hepatitis. Cannabis also acts as an antispasmodic and anticonvulsant and is indicated for neurological conditions such as epilepsy especially complex partial seizures, multiple sclerosis, and spasms. As an analgesic and an immunomodulator it is indicated for conditions such as migraine, arthritis, spinal and skeletal disorders. As a bronchodilator it is beneficial for asthma. It also reduces the intraocular pressure and is indicated for glaucoma. Recent studies have shown the drug to be efficacious in treating mood disorders and mental health issues such as depression, post traumatic stress disorder, clinical depression, obsessive-compulsive disorder, panic disorder, Crohn's Disease^[22], and bipolar disorder.[3] It is also indicated for premenstrual syndrome, hypertension, and insomnia. It is also reported to be an effective treatment for constipation.

Medical Cannabis in two bags

According to a survey on the recommendation of cannabis in California,^[23] cannabis is indicated for over 250 conditions.

Emerging medical consensus

Dozens of medical organizations have endorsed allowing patients access to medical marijuana with their physicians' approval. These include, but are not limited to, the following:

• The American College of Physicians - America's second largest physicians group^[24]
• Leukemia & Lymphoma Society - America's second largest cancer charity.^[24]
• American Academy of Family Physicians^[24]
• American Public Health Association^[24]
• American Psychiatric Association^[24]
• American Nurses Association^[24]
• British Medical Association^[24]
• AIDS Action^[24]
• American Academy of HIV Medicine^[24]
• Lymphoma Foundation of America^[24]
• Health Canada^[24]

Pharmacologic THC and THC derivatives

Canadian case of Sativex vials; the world's first artificial pharmaceutical prescription medicine derived from cannabis. Used as a mouth spray, it was first approved in Canada as adjunctive treatment for the symptomatic relief of neuropathic pain in multiple sclerosis and other conditions.

In the USA, the FDA has approved two cannabinoids for use as medical therapies: dronabinol (Marinol) and nabilone. It is important to note that these medicines are not smoked. Dronabinol is a synthetic THC medication,^[25] while nabilone is a synthetic cannabinoid marketed under the brand name Cesamet.

These medications are usually used when first line treatments for nausea fail to work. In extremely high doses and in rare cases there is a possibility of "psychotomimetic" side effects. The other commonly-used antiemetic drugs are not associated with these side effects.

The prescription drug Sativex, an extract of cannabis administered as a sublingual spray, has been approved in Canada for the treatment of multiple sclerosis;^[28] this medication may now be legally imported into the United Kingdom and Spain on prescription.^[29] Dr. William Notcutt is one of the chief researchers that has developed Sativex, he has been working with GW and founder Geoffrey Guy since the company's inception in 1998. Notcutt states that the use of MS as the disease to study "had everything to do with politics."^[30]

Criticism

See also: Health issues and the effects of cannabis

A major criticism of cannabis as medicine is opposition to smoking as a method of consumption. In contrast, the use of a vaporizer for cannabis administration delivers the active ingredients and their benefits very rapidly, without the costs associated with smoking.

On 20 April 2006, The United States Food and Drug Administration (FDA) issued an advisory against smoked medical marijuana stating that, "marijuana has a high potential for abuse, has no currently accepted medical use in treatment in the United States, and has a lack of accepted safety for use under medical supervision. Furthermore, there is currently sound evidence that smoked marijuana is harmful." [4] Some prominent American societies have been reluctant to endorse medicinal cannabis. For example: [5], the National Multiple Sclerosis Society [6] , the American Academy of Ophthalmology [7] and the American Cancer Society [8]. (Federal Register, 1992).

The Institute of Medicine, run by the United States National Academy of Sciences, conducted a comprehensive study in 1999 to assess the potential health benefits of cannabis and its constituent cannabinoids. The study concluded that smoking cannabis is not recommended for the treatment of any disease condition, but did conclude that nausea, appetite loss, pain and anxiety can all be mitigated by marijuana. While the study expressed reservations about smoked marijuana due to the health risks associated with smoking, the study team concluded that until another mode of ingestion was perfected that could provide the same relief as smoked marijuana, there was no alternative. In addition, the study pointed out the inherent difficulty in marketing a non patentable herb. Pharmaceutical companies will not substantially profit unless there is a patent. For those reasons, the Institute of Medicine concluded that there is little future in smoked cannabis as a medically approved medication. The report also concluded for certain patients, such as the terminally ill or those with debilitating symptoms, the long-term risks are not of great concern.^[31]

In an unpublished 2001 study by the Mayo Clinic, Marinol was shown to be less effective than the steroid megestrol acetate in helping cancer patients regain lost appetites.^[32] The mechanism by which megestrol acetate works is unknown and the compound can cause "impotence, gas, rash, high blood pressure, fever, decreased libido, insomnia, upset stomach, and high blood sugar. . .," as well as "breakthrough bleeding" in women.[9]

Harm reduction

Many medical cannabis opponents note that smoking cannabis is harmful to the respiratory system. However, this harm can be minimalized or eliminated by the use of a vaporizer or ingesting the drug in an edible form or other non-smoking modes of delivery like tinctures. Vaporizers are devices that vaporize the active constituents (cannabinoids) and the fragrant aromatic substances in the preparation without combusting the plant material and thus preventing the formation of toxic substances. Studies have shown that vaporizers can dramatically reduce^[33] or even eliminate^[34] the release of irritants and toxic compounds.

Aspergillus fumigatus

In order to kill microorganisms, especially mold, occasionally found in low-quality cannabis, the scientists "Levitz and Diamond (1991) suggested baking marijuana in home ovens at 150 °C [302 °F], for five minutes before smoking. Oven treatment killed conidia of A. fumigatus, A. flavus and A. niger, and did not degrade the active component of marijuana, tetrahydrocannabinol (THC)."^[35]

Availability

[] Canada

In Canada, the regulation on access to marijuana for medical purposes, established by Health Canada in July 2001, defines two categories of patients eligible for access to medical cannabis. The category 1 list individuals suffering from "acute pain", "violent nausea and/or other serious symptoms caused by the following conditions: multiple sclerosis, spinal cord injury, disease of the spinal cord, cancer, AIDS/HIV infection, severe forms of arthritis and/or epilepsy. The category 2 "key applicants who have serious pathological symptoms other than those described in category 1."^[36] The application of eligible patients must be supported by a doctor.

The cannabis distributed by Health Canada is provided under the brand CanniMed by the company Prairie Plant Systems Inc. That the demand from Canadian authorities would have increased by 80% in 2006 (the output reaching 420 kg the previous year).^[37] However, it is legal for patients approved by Health Canada to grow their own cannabis for personal consumption, and it is possible to obtain a production license as a person designated by a patient. Health Canada noted however that "no notice of compliance has been issued for marijuana for medical purposes."

Spain

In Spain, since late 1990 and early 2000, medical cannabis underwent a process of progressive decriminalization and legalization. The parliament of the region of Catalonia is the first in Spain have voted unanimously in 2001 legalizing medical marijuana, it is quickly followed by parliaments of Aragon and the Balearic Islands. The Spanish Penal Code prohibits the sale of cannabis but it does not prohibit consumption. Until early 2000, the Penal Code did not distinguish between cannabis and cannabis therapeutic recreation, however, several court decisions show that this distinction is increasingly taken into account by the judges. From 2006, the sale of seed is legalized, possession or consumption is still forbidden in public places but permitted in private premises. Moreover, the cultivation of cannabis plans is now authorized in a private place.

Several studies have been conducted to study the effects of cannabis on patients suffering from disease like cancer, AIDS, multiple sclerosis, the seizures or the asthma. This research was conducted by various Spanish agencies at the Universidad Complutense de Madrid headed by Dr. Manuel Guzman, the hospital of La Laguna in Tenerife led neurosurgeon Luis González Feria or the University of Barcelona.

After legislation, several cannabis clubs have been established including the Basque Country and Catalonia. These clubs, the first of its kind in Europe, are non-profit associations who grow cannabis and sell it at cost to its members. In 2006, members of these clubs were acquitted in trial for possession and sale of cannabis.

United States

Map of U.S. state medical marijuana laws as of June, 2008
     State with medical marijuana      State without medical marijuana

In the United States, it is important to differentiate between medical cannabis at the federal and at the state level. At the federal level, cannabis per se is made illegal and criminal by the Controlled Substances Act. Except for California, the states where medical cannabis is legal at the state level only allow it in marijuana plant form, so other forms of cannabis such as hashish, hash oil, etc. are still highly penalized.

The Federal Food, Drug, and Cosmetic Act makes the Food and Drug Administration (FDA) the sole government entity responsible for ensuring the safety and efficacy of new prescription and over-the-counter drugs, overseeing the labeling and marketing of drugs, and regulating the manufacturing and packaging of drugs.^[38] The FDA defines a drug as safe and effective for a specific indication if the clinical benefits to the patient are felt to outweigh any health risks the drug might pose. The FDA and comparable authorities in Western Europe including the Netherlands, have not approved smoked marijuana (some because of the problems related to smoking per se) for any condition or disease.^[39][40] Cannabis remains illegal throughout the United States and is not approved for prescription as medicine, although 12 states - Alaska, California, Colorado, Hawaii, Maine, Montana, Nevada, New Mexico, Oregon, Rhode Island, Vermont and Washington - approve and regulate its medical use. The federal government continues to enforce its prohibition in these states. However, there are also 2 states, Arizona and Maryland, whose drug laws are favourable towards the medicinal use of marijuana, in the later case making it a non-incarcerable offense with a maximum penalty of a $100 fine, [10] but which still explicitly ban it.

Potential health benefits aside, marijuana remains a US federally controlled substance, making possession and distribution illegal. It has been estimated that an average marijuana clinic distributes a pound of cannabis per day,^{[citation needed]} making acquisition a critical challenge. This acquisition may have to resort to more traditionally crime-associated, black-market sources, contributing to crime in communities. This point was illustrated in early 2007, with the murder of Denver, Colorado area medical cannabis activist Ken Gorman.^[41]

Researchers face similar challenges in obtaining medical cannabis for research trial. Recently, the US FDA has approved a number of cannabis research clinical trials, but the Drug Enforcement Agency has not granted licenses to the researchers in these studies.

Neon sign from a medical marijuana dispensary on Ventura Boulevard in Los Angeles, California, U.S.A.

Cannabis was listed in the United States Pharmacopeia from 1850 until 1942.^[42] The United States federal government does not currently recognize any legitimate medical use, although there are currently seven patients receiving cannabis for their various illnesses through the Compassionate Investigational New Drug program that was closed to new patients in 1991 by the George H. W. Bush administration. Francis L. Young, an administrative law judge with the United States Drug Enforcement Agency, in 1988, declared that "in its natural form, [cannabis] is one of the safest therapeutically active substances known."^[43] However, smoked cannabis is today not approved by the United States Food and Drug Administration (FDA).^[44] Twelve U.S. state laws currently allow for the medicinal use of cannabis,^[45] but the United States Supreme Court ruled that the federal government has the right to regulate and criminalize marijuana also in these states, even for medical purposes.

The term medical marijuana post-dates the U.S. Marijuana Tax Act of 1937, the effect of which made cannabis prescriptions illegal in the United States.

Alaska

The medical use of cannabis was endorsed by 58% of voters in Alaska in November 1998 and the law became effective on March 4, 1999. The law legalizes the possession, cultivation and use of cannabis for patients who have received a certificate from a doctor confirming they can benefit from the medical use of cannabis. The conditions and symptoms eligible are: cachexia, cancer, chronic pain, epilepsy and other conditions characterized by spasms, chronic glaucoma, HIV or AIDS, multiple sclerosis and nausea. The state maintains a confidential list of patients who are assigned an identity card.^[46]

California

Main article: California Proposition 215 (1996)

     California counties accepting applications for medical marijuana as of 3-25-08      California, U.S.A. counties not accepting applications as of 3-25-08

Information about medical cannabis in the U.S. western state of California can be found here: [11]. In 1996 California voted Proposition 215, also called the Compassionate Use Act, into law. CA Senate Bill 420 was passed in 2003 to clarify Proposition 215 by specifying statewide minimum limits on possession of marijuana and enact a Statewide Medical Marijuana ID Card Program. As of January 16, 2008, only 36 of 58 counties are issuing cards in the program, with 18,847 cards having been issued,^[47] however, participation in the ID Card program is optional and the identification card is not required to claim the Act's protections.^[48]

On November 5, 1996 56% of voters approved Proposition 215. The law removes state-level criminal penalties on the use, possession and cultivation of marijuana by patients who possess a "written or oral recommendation" from their physician that he or she "would benefit from medical marijuana." Patients diagnosed with any illness where the medical use of marijuana has been "deemed appropriate and has been recommended by a physician" are provided with legal protection under this act. Conditions typically covered by the law include: arthritis; cachexia; cancer; chronic pain; HIV or AIDS; epilepsy; migraine; and multiple sclerosis. No regulations regarding the amount of marijuana patients may possess and/or cultivate were provided by this act, though the California Legislature adopted guidelines in 2003.^[49]

Colorado

Information about medical marijuana in Colorado can be found here: [12]. On November 7, 2000, 54% of Colorado voters passed Amendment 20, which amends the Colorado State constitution to allow the medical use of marijuana.^[46] Patients can possess not more than 2 oz. (almost 57 g) of "usable marijuana" and not more than 6 marijuana plants, but they may neither take their medicine in public, nor even on their own property, if the public can see them taking it.^[46]

Hawaii

In Hawaii, Senate Bill 862 became law on June 14, 2000. Patients can possess a maximum of 1 ounce (28 g) of usable marijuana and a maximum of 7 marijuana plants. Information about medical marijuana in Hawaii is available at: [13].^[46]

Maine

On November 2, 1999, 62% of voters in the State of Maine (northeastern U.S.) passed Question 2. Patients or their primary physicians could possess a maximum of 1 1/4 ounces (35 g) of usable marijuana and a maximum of 6 plants. The law was amended when Maine Senate Bill 611 was signed into law on April 2, 2002, increasing the maximum quantity of usable marijuana a patient is allowed to possess to 2 1/2 ounces.^[46] Information about medical marijuana in Maine is available at www.mainecommonsense.org.

Maryland

The legislature of the U.S. eastern state of Maryland passed a "medical marijuana affirmative defense law" in the year 2003.^[46] If someone is being prosecuted by the state for certain marijuana related crimes, then the court is required by law to consider a defendant's "medical necessity."^[46] If medical necessity is proven after arrest and in court, then it is state law that the defendant can only be presented with a $100 fine at the state level.^[46]

Montana

On November 2, 2004, voters of the U.S. northwestern state of Montana passed Initiative 148, which took effect immediately.^[46] It eliminates criminal sanctions at the state level for medical marijuana authorized by a patient's physician.^[46] Possession of as many as six marijuana plants is allowed.^[46]

More information on medical marijuana in Montana is available here: [14].

Nevada

On November 7, 2000 voters in the U.S. western state of Nevada passed Question 9, amending the state constitution to allow for medical marijuana.^[46] The state law provides that medical marijuana patients may possess a maximum of 1 ounce (28 g) of usable marijuana and grow a maximum of 7 marijuana plants.^[46]

New Mexico

On April 2, 2007 the governor of the southwestern U.S. state of New Mexico approved Senate Bill 523, which legalizes medical marijuana for patients authorized by the state.^[46] More information can be found at: [15].

Oregon

Main article: Oregon Medical Marijuana Act

Information about medical cannabis in the U.S. western state of Oregon can be found here: [16]. The Oregon medical cannabis program has the name, "The Oregon Medical Marijuana Program," which administers the Medical Marijuana Act approved there by the public in November of 1998.^[50] The Oregon Medical Marijuana Program administers the program within the Oregon Department of Human Services. As of April 1, 2008, there were 16,635 patients registered.^[51] Virtually all patients benefiting from the program suffer from severe pain and almost 2500 from nausea. The other conditions are given as epilepsy, AIDS / HIV, cancer, cachexia, chronic glaucoma and tremors caused by Alzheimer's disease.^[52]

Rhode Island

On January 3, 2006, in the eastern U.S. state of Rhode Island, The Edward O. Hawkins and Thomas C. Slater Medical Marijuana Act (Rhode Island) became law and simultaneously went into effect.^[46] It legalizes medical marijuana at the state level, provided that certain conditions are met. Patients can possess a maximum of 2.5 ounces of marijuana and a maximum of 12 marijuana plants.^[46]

More information is available at: [17].

State of Washington

The State of Washington (northwestern U.S.) adopted a law via elections in November 1998 (Initiative 692), legalizing the use, possession and cultivation of cannabis for patients with a medical certificate. The conditions are eligible the following: cachexia, cancer, HIV or AIDS, epilepsy, glaucoma, chronic pain otherwise intractable, and multiple sclerosis. According to the law in Washington [18], a patient prescribed medical marijuana may only keep a 60 day supply of it.^[53]

Vermont

In the northeastern U.S. state of Vermont, Senate Bill 76 went into effect July 1, 2004, legalizing medical marijuana at the state level, provided certain conditions are met.^[46] Patients or their primary doctor are allowed to possess a maximum of 2 ounces of usable marijuana and a maximum of 3 marijuana plants, a maximum of which one can be mature.^[46]

Amendments

Vermont Senate Bill 7 went into effect July 1, 2007 further defining which patients qualify for medical marijuana and how much they may possess without penalty of law at the state level.^[46] The amendment allows physicians licensed outside of Vermont to recommend medical marijuana for Vermont patients.^[46]

More information about medical marijuana in Vermont is available here: [19].

Legal and medical status of cannabis

Main article: Legal and medical status of cannabis

European laws on cannabis possession (small amount). Data are from multiple sources detailed on the full source list

Cannabis is in Schedule IV of the Single Convention on Narcotic Drugs, making it subject to special restrictions. Article 2 provides for the following, in reference to Schedule IV drugs:

A Party shall, if in its opinion the prevailing conditions in its country render it the most appropriate means of protecting the public health and welfare, prohibit the production, manufacture, export and import of, trade in, possession or use of any such drug except for amounts which may be necessary for medical and scientific research only, including clinical trials therewith to be conducted under or subject to the direct supervision and control of the Party.

This provision, while apparently providing for the limitation of cannabis to research purposes only, also seems to allow some latitude for nations to make their own judgments. The official Commentary on the Single Convention indicates that Parties are expected to make that judgment in good faith.

Notable pro- and anti-medical cannabis individuals

[] Proponents

Pro-cannabis demonstrators in Los Angeles, California, August 2007.

(Scientists, authors, artists, musicians and other scholars)

• Carl Sagan, Ph.D. - American astronomer and astrochemist.
• Ron Paul, M.D., U.S. Congressman and Republican candidate in the 2008 United States presidential election.^[54]
• Ann Druyan - wife of Carl Sagan, one of the writers of Cosmos: A Personal Voyage.
• Drew Carey- Comedian, host of The Price is Right
• Willie Nelson - Singer and songwriter.
• William F. Buckley - conservative Republican commentator, publisher of the National Review.
• Dennis Peron - co-author of 215, along with Anna Boyce, Dale Gieringer, Scott Imler, Bill Panzer, Leo Paoli, and Valerie Corral.
• Lester Grinspoon, M.D., - Professor of Medicine, Harvard; author of Marijuana, the Forgotten Medicine
• Jay Cavanaugh, Ph.D. - California State Board of Pharmacy 1980-90, National Director American Alliance for Medical Cannabis 2001.
• Christopher Hitchens spoke as a proponent of medical marijuana in the 2007 documentary film In Pot We Trust.^[55]
• Cypress Hill - American rap group
• Angel Raich - U.S. activist, respondent in Gonzales v. Raich.
• Ed Rosenthal - A horticulturist that fights for the right to grow marijuana for medicinal purposes.
• Fred Gardner - "the chronicler of the movement", published in CounterPunch and other prominent publications and author of O'Shaunessey's, the Journal of the California Cannabis Research Medical Group.
• Steve Kubby - Key Organizer of California's Proposition 215, Founder and National Director American Medical Marijuana Association.
• Peter McWilliams - Author who used cannabis to relieve pain.
• Rick Steves - PBS Travel Show Host and on NORML's advisory board.
• Rob Kampia - Founder of Marijuana Policy Project.
• Dana Rohrabacher - United States Congressman who proposed a bill to stop Department of Justice from arresting medical cannabis patients.
• Bill Maher - Comedian and host of Real Time with Bill Maher on HBO.
• Ethan Nadelmann - President of Drug Policy Alliance.
• Bill Mescher - A South Carolina state senator who proposed legalization of medical cannabis.
• Keith Stroup - Founder of NORML.
• Penn Jillette - Of Penn and Teller, although he has never used recreational drugs.
• Woody Harrelson - American actor.
• Snoop Dogg - American rap artist.
• Bobby Steele

Medical cannabis protest

• Stephen Jay Gould - American paleontologist and evolutionary biologist.
• Montel Williams - talk show host, after using it to alleviate symptoms of multiple sclerosis.^[56]
• Loretta Nall - Founder of the United States Marijuana party
• Robert Anton Wilson - novelist, essayist, philosopher, futurologist, libertarian, and founder of the Guns and Dope Party
• Jack Herer - California Cannabis Hemp & Health Initiative 2008, Long Time Activist
• Marc Emery - Cannabis Culture Magazine, former seed merchant facing extradition to the US.
• Dennis Kucinich - Democratic United States Representative from Ohio and Presidential Candidate in 2004 and 2008.
• Rob Van Dam - professional wrestler
• Jack Black - actor and musician, best known for being the lead vocalist for Tenacious D.
• Kyle Gass - actor and musician, second member and lead guitarist for Tenacious D.
• Robert Randall - co-founder of the Alliance for Cannabis Therapeutics, a medical marijuana advocacy organization, and the first person to mount a successful medical necessity defense to marijuana charges in a U.S. federal criminal case^[57]
• Jim Klahr - musician - Co-establisher and member of BoD of Oregon Green Free[20] and Advisor on DHS/OMMP advisory committee on medical marijuana.

Opponents

(Primarily government employees)

Medicinal cannabis plant

• Hamid Ghodse - International Narcotics Control Board president.
• Hal Lindsey - Author, former talkshow host, and prophecy scholar. Supports the use of THC pills but opposes the smoking of cannabis for medicinal purposes.
• John P. Walters - Current Director of the White House Office of National Drug Control Policy of United States.
• Mark Souder - U.S. Congressman who filed an amicus brief in support of the U.S. government in Gonzales v. Raich. The federal government may ban the use of marijuana even where states approve its use for medicinal purposes.
• Andrea Barthwell - Former deputy director of the White House Office of National Drug Control Policy under George W. Bush.
• Paul Clement - Current Solicitor General who argued on behalf of the federal government in Gonzales v. Raich.
• Dan Lungren - Former Attorney General of California who presided over crackdown of medical marijuana dispensaries.
• Rush Limbaugh - Nationally syndicated radio talk show host and noted prescription opiate addict.^[58]
• Asa Hutchinson - Former Administrator of the Drug Enforcement Administration.^[59]
• Richard Carmona - Former U.S. Surgeon General.^[60]
• William Bennett - Former Director of the Office of National Drug Control Policy.^[61]
• Mitt Romney Republican candidate in the 2008 United States presidential election.^[62]
• George H. W. Bush - 41st President of the United States.
• George W. Bush - President of the United States, 2001-Present.
• Eliot Spitzer - Former Governor of New York.
• Barry McCaffrey - Former Director of the Office of National Drug Control Policy.^[63]
• Theodore Sophocleus - Democrat Maryland Delegate.^[64]
• Carol Lam - Former California United States Attorney.
• Bonnie Dumanis - Current District Attorney for San Diego County, California.^[65]
• Bill Clinton - 42nd President of the United States, 1993-2001.^{[citation needed]}
• Janet Reno - Former United States Attorney General.^[66]
• Donna Shalala - Former Secretary of Health and Human Services.
• Robert L. DuPont, M.D. - President Institute For Behavior and Health.

Further reading

• Official FDA Statement Regarding Claims of Smoked Marijuana as medicine
• Report on and index of marijuana medical studies by Todd Mikuriya, M.D.]
• Cannabis-In-Cachexia-Study-Group; Strasser F, Luftner D, Possinger K, Ernst G, Ruhstaller T, Meissner W, Ko YD, Schnelle M, Reif M, Cerny T: Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia-Study-Group. J Clin Oncol. 2006 Jul 20;24(21):3394-400.
  • Synthetic THC or low doses of cannabis extract administered orally for cancer-related cachexia (anorexia, weight-loss, emaciation) not better than placebo.
• Janet E. Joy, Stanley J. Watson, Jr., and John A Benson, Jr., "Marijuana and Medicine: Assessing the Science Base", Division of Neuroscience and Behavioral Research, Institute of Medicine (Washington, DC: National Academy Press, 1999).
  • "The accumulated data indicate a potential therapeutic value for cannabinoid drugs, particularly for symptoms such as pain relief, control of nausea and vomiting, and appetite stimulation." and "At this point there are no convincing data to support (the concern that medical marijuana would lead to an increase in recreational use). The existing data are consistent with the idea that this would not be a problem if the medical use of marijuana were as closely regulated as other medications with abuse potential."
• Index of studies involving marijuana and multiple sclerosis
• Doblin et al., Marijuana as Antiemetic Medicine: A Survey of Oncologists' Experiences and Attitudes," Journal of Clinical Oncology, Vol. 9, No. 7, July 1991.
• Khamsi, R: Cannabis compound benefits blood vessels. Nature, 4 Apr 2005 (premium content).
  • THC has been found to combat formation of arterial blockages. A random survey of oncologists found that 44% had illegally recommended marijuana for the control of vomiting and that 48% would do so if it were legal; 54% thought it should be available by prescription.
• Vinciguerra et al., Inhalation Marijuana as an Antiemetic for Cancer Chemotherapy," The New York State Journal of Medicine, pgs., 525-527, October 1988
  • 56 Patients who had achieved no success with other antiemetics; 72% found success — the study also concluded that smoked marijuana was more effective than oral THC pills.
• Chang et al., Delta-9-Tetrahydrocannabinol as an Antiemetic in Cancer Patients Receiving High Dose Methotrexate; Annals of Internal Medicine, Volume 91, Number 6, pg. 819-824, December 1979
  • A double-blind controlled study found a 72% reduction in nausea and vomiting; the study also concluded that smoked marijuana was more effective than oral THC
• Foltin RW, Brady JV, Fischman MW: Behavioral analysis of marijuana effects on food intake in humans. Pharmacol Biochem Behav. 1986 Sep;25(3):577-82.; RW, Fischman MW, Byrne MF: Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory. Appetite. 1988 Aug;11(1):1-14.; and Greenberg I, Kuehnle J, Mendelson JH, Bernstein JG: Effects of marihuana use on body weight and caloric intake in humans. Psychopharmacology (Berl). 1976 Aug 26;49(1):79-84.
  • These three studies concluded that marijuana increases appetite.
• Sallan SE, Zinberg NE, Frei E 3rd: Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy. N Engl J Med. 1975 Oct 16;293(16):795-7.
  • Study concluded that smoked marijuana was more beneficial than synthetic THC for some patients.
• Donald P. Tashkin, MD, "Effects of Smoked Marijuana on the Lung and Its Immune Defenses: Implications for Medicinal Use in HIV-Infected Patients"; Journal of Cannabis Therapeutics, Vol. 1, No. 3/4, 2001, pp. 87-102
  • "Frequent marijuana use can cause airway injury, lung inflammation and impaired pulmonary defense against infection. The major potential pulmonary consequences of habitual marijuana use of particular relevance to patients with AIDS is superimposed pulmonary infection, which could be life threatening in the seriously immonocompromised patient. In view of the immonosuppressive effect of THC, the possibility that regular marijuana use could enhance progression of HIV infection itself needs to be considered, although this possibility remains unexplored to date."
• Guy A. Cabral, PhD, "Marijuana and Cannabinoids: Effects on Infections, Immunity, and AIDS"; Journal of Cannabis Therapeutics, Vol. 1, No. 3/4, 2001, pp. 61-85
  • "However, few controlled longitudinal epidemiological and immunological studies have been undertaken to correlate the immunosuppressive effects of marijuana smoke or cannabinoids on the incidence of infections or viral disease in humans. Clearly, additional investigation to resolve the long-term immunological consequences of cannabinoid and marijuana use as they relate to resistance to infections in humans is warranted."
• Ekert H, Waters KD, Jurk IH, Mobilia J, Loughnan P: Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-tetrahydrocannabinol. Med J Aust. 1979 Dec 15;2(12):657-9.
  • In children receiving cancer chemotherapy delta-9-tetrahydrocannabinol (THC) has an antinausea and antivomiting effect.
• Sallan SE, Cronin C, Zelen M, Zinberg NE: Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine. N Engl J Med. 1980 Jan 17;302(3):135-8.
  • THC seems to be an effective antiemetic in many patients who receive chemotherapy for cancer and for whom other antiemetics are ineffective.
• New Studies Destroy the Last Objection to Medical Marijuana

Gallery

Image:Drug bottle containing cannbis.jpg|Cannabis Indica, Fluid Extract, American Druggists Syndicate, pre-1937

See also

• California Cannabis Research Medical Group
• Cannabis Buyers Club
• Ed Rosenthal
• Health issues and the effects of cannabis
• Legality of cannabis by country
• Multidisciplinary Association for Psychedelic Studies
• NORML
• Patients Out of Time
• Proposition 215
• Sativex
• Steve Kubby
• Tilden's Extract
• United States v. Oakland Cannabis Buyers' Cooperative
• Victor Robinson
• Oregon Green Free

References

• Single Convention on Narcotic Drugs 1961, International Narcotics Control Board.
• Dominik Wujastyk, "Cannabis in Traditional Indian Herbal Medicine" in Ana Salema (ed.), Ayurveda at the Crossroads of Care and Cure, Lisbon, Centro de História del Além-Mar, Universidade Nova de Lisboa, 2002, pp.45--73. ISBN 972-98672-5-9. Early pre-publication draft.

Notes