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Jun D proto-oncogene, also known as JUND, is a human gene.
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms.[1]
See also
References
Further reading
- Mollinedo F, Vaquerizo MJ, Naranjo JR (1991). "Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.". Biochem. J. 273(Pt 2): 477–9. PMID 1899335.
- Berger I, Shaul Y (1991). "Structure and function of human jun-D.". Oncogene 6 (4): 561–6. PMID 1903194.
- Nomura N, Ide M, Sasamoto S, et al. (1990). "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D.". Nucleic Acids Res. 18 (10): 3047–8. PMID 2112242.
- Franklin CC, McCulloch AV, Kraft AS (1995). "In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB.". Biochem. J. 305 ( Pt 3): 967–74. PMID 7848298.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
- Chu HM, Tan Y, Kobierski LA, et al. (1994). "Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression.". Mol. Endocrinol. 8 (1): 59–68. PMID 8152431.
- Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133–45. PMID 8432525.
- Dorsey MJ, Tae HJ, Sollenberger KG, et al. (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.". Oncogene 11 (11): 2255–65. PMID 8570175.
- Claret FX, Hibi M, Dhut S, et al. (1996). "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.". Nature 383 (6599): 453–7. doi:10.1038/383453a0. PMID 8837781.
- Kallunki T, Deng T, Hibi M, Karin M (1997). "c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions.". Cell 87 (5): 929–39. PMID 8945519.
- Aronheim A, Zandi E, Hennemann H, et al. (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.". Mol. Cell. Biol. 17 (6): 3094–102. PMID 9154808.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
- Labudova O, Krapfenbauer K, Moenkemann H, et al. (1998). "Decreased transcription factor junD in brains of patients with Down syndrome.". Neurosci. Lett. 252 (3): 159–62. PMID 9739985.
- Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.". Oncogene 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. PMID 9872330.
- Agarwal SK, Guru SC, Heppner C, et al. (1999). "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.". Cell 96 (1): 143–52. PMID 9989505.
- Liberati NT, Datto MB, Frederick JP, et al. (1999). "Smads bind directly to the Jun family of AP-1 transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. PMID 10220381.
- Gobl AE, Berg M, Lopez-Egido JR, et al. (1999). "Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism.". Biochim. Biophys. Acta 1447 (1): 51–6. PMID 10500243.
- Ubeda M, Vallejo M, Habener JF (1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins.". Mol. Cell. Biol. 19 (11): 7589–99. PMID 10523647.
- Miyamoto NG, Medberry PS, Hesselgesser J, et al. (2000). "Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors.". J. Neuroimmunol. 105 (1): 78–90. PMID 10713367.
- Sharma SC, Richards JS (2000). "Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation.". J. Biol. Chem. 275 (43): 33718–28. doi:10.1074/jbc.M003555200. PMID 10934195.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Transcription factors and intracellular receptors |
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(1) Basic domains |
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Activating transcription factor ( AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 ( c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH ( 1, 2) • BATF • BLZF1 • C/EBP ( a, ß, ?, d, e, ?) • CREB ( 1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF ( B, F, G, K) • NFE ( 2, L1, L2) • NRL • NRF1 • XBP1
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(1.2) Basic helix-loop-helix ( bHLH)
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ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL ( ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND ( 1, 2) • HES ( 5, 6) • HEY ( 1, 2, L) • HES1 • HIF ( 1A, 3A) • ID ( 1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors ( MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD ( 1, 2) • NPAS ( 1, 2, 3) • OLIG ( 1, 2) • Scleraxis • TAL1 • Twist • USF1
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(1.4) NF-1
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(1.5) RF-X
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(1.6) Basic helix-span-helix (bHSH)
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(2) Zinc finger DNA-binding domains |
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subfamily 1 ( Thyroid hormone ( a, ß), CAR, FXR, LXR ( a, ß), PPAR ( a, ß/d, ?), PXR, RAR ( a, ß, ?), ROR ( a, ß, ?), Rev-ErbA ( a, ß), VDR)
subfamily 2 ( COUP-TF ( I, II), Ear-2, HNF4 ( a, ?), PNR, RXR ( a, ß, ?), Testicular receptor ( 2, 4), TLX)
subfamily 3 ( Steroid hormone ( Androgen, Estrogen ( a, ß), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related ( a, ß, ?))
subfamily 4 NUR ( NGFIB, NOR1, NURR1) • subfamily 5 ( LRH-1, SF1) • subfamily 6 ( GCNF) • subfamily 0 ( DAX1, SHP)
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(2.2) Other Cys4
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(2.3) Cys2His2
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General transcription factors ( TFIIA, TFIIB, TFIID, TFIIE, TFIIF ( 1, 2), TFIIH ( 1, 2, 4, 2I, 3A, 3C1, 3C2))
ATBF1 • BCL ( 6, 11A, 11B) • CTCF • E4F1 • EGR ( 2, 3) • ERV3 • GFI1 • GLI-Krüppel family ( 1, 2, 3, S2, YY1) • HIC ( 1, 2) • HIVEP ( 1, 2, 3) • IKZF ( 1, 2, 3) • ILF ( 2, 3) • KLF ( 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17 ) • MTF1 • MYT1 • OSR1 • SP ( 1, 2, 4, 7) • Zbtb7 ( 7A, 7B) • ZBTB ( 16, 17, 20, 32, 33, 40) • zinc finger ( 3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 649, 655)
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(2.4) Cys6
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(2.5) Alternating composition
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(3) Helix-turn-helix domains |
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ARX • CDX ( 1, 2) • CRX • CUTL1 • DLX ( 3, 4, 5) • EMX2 • EN ( 1, 2) • FHL ( 1, 2, 3) • HESX1 • HHEX • HLX • Homeobox ( A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS ( 1, 2) • MEOX2 • MNX1 • MSX ( 1, 2) • NANOG • NKX ( 2-1, 2-2, 2-3, 2-5, 3-1, 3-2) • PBX ( 1, 2, 3) • PHF ( 1, 3, 6, 8, 10, 16, 17, 20, 21A) • PITX ( 1, 2, 3) • POU domain ( PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) • OTX ( 1, 2) • PDX1
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(3.2) Paired box
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E2F ( 1, 2, 3, 4, 5) • FOX proteins ( C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, O3A, O4, P1, P2, P3)
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(3.5) Tryptophan clusters
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ELF ( 4, 5) • EGF • ELK ( 1, 3, 4) • ERF • ERG • ETS ( 1, 2, SPIB) • ETV ( 1, 4, 5, 6) • FLI1 • Interferon regulatory factors ( 1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
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(3.6) TEA domain
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transcriptional enhancer factor 1, 2
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(4) ß-Scaffold factors with minor groove contacts |
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(4.1) Rel homology region
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(4.3) p53
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HMGB ( 1, 2, 3) • HNF ( 1A, 1B) • LEF1 • SOX ( 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) • SRY • SSRP1 • TOX ( 1, 2, 3, 4)
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(4.10) Cold-shock domain
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(4.11) Runt
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(0) Other transcription factors |
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(0.2) HMGI(Y)
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(0.6) Miscellaneous
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ARID ( 1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI ( 16, 35) • MLL ( 2, 3, T1) • MNDA • NFI ( A, B, C, X) • NFY ( A, B, C) • Rho/ Sigma • R-SMAD
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