In enzymology, an isopropanol dehydrogenase (NADP+) (EC 1.1.1.80) is an enzyme that catalyzes the chemical reaction

propan-2-ol + NADP⁺ acetone + NADPH + H⁺

Thus, the two substrates of this enzyme are propan-2-ol and NADP⁺, whereas its 3 products are acetone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is propan-2-ol:NADP+ oxidoreductase. This enzyme is also called isopropanol dehydrogenase (NADP+). This enzyme participates in propanoate metabolism.

References

• IUBMB entry for 1.1.1.80
• BRENDA references for 1.1.1.80 (Recommended.)
• PubMed references for 1.1.1.80
• PubMed Central references for 1.1.1.80
• Google Scholar references for 1.1.1.80
• Hoshino K (1960). "Organism producing isopropanol from acetone. V. Enzymological [studies] on the oxidation-reduction of Lactobacillus brevis var hofuensis. [in Japanese]". Nippon Nogei Kagaku Kaishi 34: 608–615. 
• Hoshino K and Udagawa K (1960). "Organism producing isopropanol from acetone. VI. Isopropanol dehydrogenase and alcohol dehydrogenase of Lactobacillus brevis var hofuensis. [in Japanese]". Nippon Nogei Kagaku Kaishi 34: 616–619. 

External links

The CAS registry number for this enzyme class is 37250-18-3.

• IUBMB entry for 1.1.1.80

• KEGG entry for 1.1.1.80

• BRENDA entry for 1.1.1.80

• NiceZyme view of 1.1.1.80

• EC2PDB: PDB structures for 1.1.1.80

• PRIAM entry for 1.1.1.80

• PUMA2 entry for 1.1.1.80

• IntEnz: Integrated Enzyme entry for 1.1.1.80

• MetaCyc entry for 1.1.1.80

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0050009: isopropanol dehydrogenase (NADP+)

• AMIGO entry for GO code 0050009: isopropanol dehydrogenase (NADP+)

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