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FOS-like antigen 1, also known as FOSL1, is a human gene.[1]
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[1]
See also
References
Further reading
- Herdegen T, Leah JD (1999). "Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.". Brain Res. Brain Res. Rev. 28 (3): 370490. PMID 9858769.
- Reddy SP, Mossman BT (2002). "Role and regulation of activator protein-1 in toxicant-induced responses of the lung.". Am. J. Physiol. Lung Cell Mol. Physiol. 283 (6): L116178. doi:10.1152/ajplung.00140.2002. PMID 12424143.
- Matsui M, Tokuhara M, Konuma Y, et al. (1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation.". Oncogene 5 (3): 24955. PMID 2107490.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 1714. PMID 8125298.
- Tsuchiya H, Fujii M, Niki T, et al. (1993). "Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals.". J. Virol. 67 (12): 70017. PMID 8230424.
- Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A (1994). "Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13.". Genomics 18 (1): 165. PMID 8276409.
- Courseaux A, Grosgeorge J, Gaudray P, et al. (1997). "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Nιoplasies Endocriniennes Multiples de type 1).". Genomics 37 (3): 35465. PMID 8938448.
- Arts J, Herr I, Lansink M, et al. (1997). "Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro.". Nucleic Acids Res. 25 (2): 3117. PMID 9016559.
- Pognonec P, Boulukos KE, Aperlo C, et al. (1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity.". Oncogene 14 (17): 20918. doi:10.1038/sj.onc.1201046. PMID 9160889.
- Smith CM, Ma NS, Nowak NJ, et al. (1997). "A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13.". Genome Res. 7 (8): 83542. PMID 9267807.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 14956. PMID 9373149.
- Puntschart A, Wey E, Jostarndt K, et al. (1998). "Expression of fos and jun genes in human skeletal muscle after exercise.". Am. J. Physiol. 274 (1 Pt 1): C12937. PMID 9458721.
- Finzer P, Soto U, Delius H, et al. (2000). "Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition.". Oncogene 19 (29): 323544. doi:10.1038/sj.onc.1203643. PMID 10918580.
- Udalova IA, Kwiatkowski D (2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region.". Biochem. Biophys. Res. Commun. 289 (1): 2533. doi:10.1006/bbrc.2001.5929. PMID 11708771.
- Jardine H, MacNee W, Donaldson K, Rahman I (2002). "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1.". J. Biol. Chem. 277 (24): 2115866. doi:10.1074/jbc.M112145200. PMID 11912197.
- Wang HL, Wang J, Xiao SY, et al. (2002). "Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.". Int. J. Cancer 101 (4): 30110. doi:10.1002/ijc.10630. PMID 12209953.
- Bergman MR, Cheng S, Honbo N, et al. (2003). "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers.". Biochem. J. 369 (Pt 3): 48596. doi:10.1042/BJ20020707. PMID 12371906.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899903. doi:10.1073/pnas.242603899. PMID 12477932.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Transcription factors and intracellular receptors |
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(1) Basic domains |
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Activating transcription factor ( AATF, 1, 2, 3, 4, 5, 6, 7) AP-1 ( c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) BACH ( 1, 2) BATF BLZF1 C/EBP ( a, ί, ?, d, e, ?) CREB ( 1, 3, L1) CREM DBP DDIT3 GABPA HLF MAF ( B, F, G, K) NFE ( 2, L1, L2) NRL NRF1 XBP1
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(1.2) Basic helix-loop-helix ( bHLH)
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ATOH1 AhR AHRR ARNT ASCL1 BHLHB2 BMAL ( ARNTL, ARNTL2) CLOCK EPAS1 HAND ( 1, 2) HES ( 5, 6) HEY ( 1, 2, L) HES1 HIF ( 1A, 3A) ID ( 1, 2, 3, 4) LYL1 MXD4 MYCL1 MYCN Myogenic regulatory factors ( MyoD, Myogenin, MYF5, MYF6) Neurogenins NeuroD ( 1, 2) NPAS ( 1, 2, 3) OLIG ( 1, 2) Scleraxis TAL1 Twist USF1
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(1.4) NF-1
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(1.5) RF-X
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(1.6) Basic helix-span-helix (bHSH)
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(2) Zinc finger DNA-binding domains |
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subfamily 1 ( Thyroid hormone ( a, ί), CAR, FXR, LXR ( a, ί), PPAR ( a, ί/d, ?), PXR, RAR ( a, ί, ?), ROR ( a, ί, ?), Rev-ErbA ( a, ί), VDR)
subfamily 2 ( COUP-TF ( I, II), Ear-2, HNF4 ( a, ?), PNR, RXR ( a, ί, ?), Testicular receptor ( 2, 4), TLX)
subfamily 3 ( Steroid hormone ( Androgen, Estrogen ( a, ί), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related ( a, ί, ?))
subfamily 4 NUR ( NGFIB, NOR1, NURR1) subfamily 5 ( LRH-1, SF1) subfamily 6 ( GCNF) subfamily 0 ( DAX1, SHP)
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(2.2) Other Cys4
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(2.3) Cys2His2
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General transcription factors ( TFIIA, TFIIB, TFIID, TFIIE, TFIIF ( 1, 2), TFIIH ( 1, 2, 4, 2I, 3A, 3C1, 3C2))
ATBF1 BCL ( 6, 11A, 11B) CTCF E4F1 EGR ( 2, 3) ERV3 GFI1 GLI-Krόppel family ( 1, 2, 3, S2, YY1) HIC ( 1, 2) HIVEP ( 1, 2, 3) IKZF ( 1, 2, 3) ILF ( 2, 3) KLF ( 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17 ) MTF1 MYT1 OSR1 SP ( 1, 2, 4, 7) Zbtb7 ( 7A, 7B) ZBTB ( 16, 17, 20, 32, 33, 40) zinc finger ( 3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 649, 655)
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(2.4) Cys6
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(2.5) Alternating composition
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(3) Helix-turn-helix domains |
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ARX CDX ( 1, 2) CRX CUTL1 DLX ( 3, 4, 5) EMX2 EN ( 1, 2) FHL ( 1, 2, 3) HESX1 HHEX HLX Homeobox ( A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) HOPX MEIS ( 1, 2) MEOX2 MNX1 MSX ( 1, 2) NANOG NKX ( 2-1, 2-2, 2-3, 2-5, 3-1, 3-2) PBX ( 1, 2, 3) PHF ( 1, 3, 6, 8, 10, 16, 17, 20, 21A) PITX ( 1, 2, 3) POU domain ( PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) OTX ( 1, 2) PDX1
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(3.2) Paired box
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E2F ( 1, 2, 3, 4, 5) FOX proteins ( C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, O3A, O4, P1, P2, P3)
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(3.5) Tryptophan clusters
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ELF ( 4, 5) EGF ELK ( 1, 3, 4) ERF ERG ETS ( 1, 2, SPIB) ETV ( 1, 4, 5, 6) FLI1 Interferon regulatory factors ( 1, 2, 3, 4, 5, 6, 7, 8) MYB MYBL2
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(3.6) TEA domain
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transcriptional enhancer factor 1, 2
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(4) ί-Scaffold factors with minor groove contacts |
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(4.1) Rel homology region
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(4.3) p53
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HMGB ( 1, 2, 3) HNF ( 1A, 1B) LEF1 SOX ( 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) SRY SSRP1 TOX ( 1, 2, 3, 4)
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(4.10) Cold-shock domain
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(4.11) Runt
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(0) Other transcription factors |
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(0.2) HMGI(Y)
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(0.6) Miscellaneous
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ARID ( 1A, 1B, 2, 3A, 3B, 4A) CAP IFI ( 16, 35) MLL ( 2, 3, T1) MNDA NFI ( A, B, C, X) NFY ( A, B, C) Rho/ Sigma R-SMAD
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